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Norco dosage9/7/2023 Instruct pts not to consume alcoholic beverages or use alcohol-containing prescription or non-prescription medications while taking hydrocodone ER cap form alcohol consumption during tx may result in incr. depression monitor pts receiving any concomitant CYP450 3A4 inhibitor or inducer Avoid Alcohol hydrocodone levels and may cause potentially fatal resp. Providers are strongly encouraged to complete risk evaluation and mitigation strategy (REMS)-compliant education program, counsel pts and/or caregivers w/ each Rx on serious risks, safe use, and importance of reading medication guide CYP450 3A4 InteractionĬoncomitant use w/ CYP450 3A4 inhibitors or D/C of concomitant CYP450 3A4 inducers may incr. at delivery if extended opioid use required Opioid Analgesic REMS depression, coma, and death reserve concomitant use for pts w/ inadequate alternative tx options Neonatal Opioid Withdrawal SyndromeĮxtended use in pregnant pts can lead to potentially life-threatening neonatal opioid withdrawal syndrome advise pregnant pts of risks and ensure tx by neonatology experts avail. alcohol, may result in profound sedation, resp. by children, can result in fatal hydrocodone overdose Risks from Concomitant Use w/ Benzodiazepines, CNS DepressantsĬoncomitant opioid use w/ benzodiazepines or other CNS depressants, incl. risk, initiate and titrate dose appropriately instruct pts to swallow ER caps or ER tabs whole crushing, chewing, or dissolving ER caps or ER tabs can cause rapid release and absorption of potentially fatal hydrocodone dose Accidental IngestionĪccidental ingestion of even one dose, esp. during tx start or after dose incr to decr. Serious, life-threatening, or fatal cases may occur even w/ recommended use, esp. Opioid agonist Schedule II controlled substance w/ risk of addiction, abuse, and misuse, which can lead to overdose and death assess opioid abuse or addiction risk prior to prescribing regularly reassess all pts for misuse, abuse, and addiction Respiratory Depression depression risk Addiction, Abuse, and Misuse Should only be prescribed by healthcare professionals knowledgeable in use of potent opioids for chronic pain management reserve extended-release and long-acting formulations for pts w/o tx alternatives not indicated for prn analgesic use proper dosing and titration essential to decr.
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